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We needed to see that waltz and the machinery in motion in order to understand how to gum up this Swiss watch.” “The molecules move in a complicated pattern, like a waltz. “It’s critical to be able to see the interactions between the nonstructural proteins (which are mostly enzymes) as they process the viral RNA one base at a time,” Ramanathan said. But static images alone wouldn’t be enough to capture the workings of the copying process. The team used data from cryo-electron microscopy, a technique that flash-freezes molecules and pounds them with electrons to create 3D images, to take a closer look at the molecular machinery. “A number of scientists have done tremendous work to understand some of these individual parts, but nobody had looked at this complex from a broader view to try to understand how they all work together.” “It’s a system of roughly 2 million atoms, and there’s no single way to get a really good look inside,” Ramanathan said. The process essentially transcribes the ribonucleic acid, or RNA, that contains the genetic code for the virus, packages the RNA and pumps out the photocopies of itself to overwhelm the host cells. The coronavirus uses a precisely coordinated process known as the replication-transcription complex to reproduce at high speed when it invades a host’s cells. The prize will be presented at this year’s SC21 conference, Nov. The study earned the multi-institutional team a finalist nomination for the Association of Computing Machinery ( ACM) Gordon Bell Special Prize for High Performance Computing–Based COVID-19 Research. But first we had to better understand it.” “If we could find ways to block or gum up the copying process, we could discover new drugs to attack the virus. Department of Energy’s ( DOE) Argonne National Laboratory and the study’s lead author. “Think of it as like a Swiss watch, with precisely organized enzymes and nanomachines that come together like tiny gears to perform this function,” said Arvind Ramanathan, a computational scientist at the U.S. To find weapons to fight the coronavirus, scientists used the nation’s fastest supercomputer to peer inside the intricacies of how the virus reproduces itself. Depart VFR and contact Terminal Radar Approach Control (TRACON)/Air Route Traffic Control Center (ARTCC) while VFR airborne.At an uncontrolled field, if a clearance is required, you may:.Clearance Delivery Phone Number Example.See also: 7 Ways To Pick Up Your IFR Clearance At A Non-Towered Airport.If operating at an airfield that does not have an organic clearance delivery, then the clearance, control information, or a response to a request for information originated by an ATC facility and relayed to the pilot through an air-to-ground communication station will be prefixed with: " ATC clears," " ATC advises," or " ATC requests".The reason for the change of flight plan is a line of a severe thunderstorm in the vicinity of Jacksonville"" Contact Meridian Departure Control on two seven six point four. Expect flight level two seven zero ten minutes after takeoff. Maintain runway heading for vectors on course. ATC: " Cessna One Seven Two Seven Victor, is cleared to Navy Pensacola via direct Montgomery, Pecan, Valdosta, Tallahassee, then as filed.ATC: ", I have your clearance, advise when ready to copy".Pilot: " clearance, with, IFR to on request" OR simply " clearance, IFR to ".Pilot: " Danbury Clearance, Cessna One Seven Two Seven Victor at Arrow, Information Alpha, VFR to the west, requesting 4,500".The complexity of the radio call depends upon if the pilot is departing under Visual Flight Rules (VFR) or Instrument Flight Rules (IFR).Before calling for a clearance, however, pilots must listen to the Automated Terminal Informatino Service or Automated Surface Observing System (ASOS)/Automated Weather Observing System (AWOS) to receive local weather/NOTAMs as well as the information code. Clearances may, however, be obtained via Flight Service via phone, or radio, approach control, ARTCC, via a relay clearance.Pilots generally obtain their clearance by contacting clearance delivery or ground before engine start.Reading back a clearance implies acceptance unless you reject it and give a reason in favor of receiving an amended clearance.A clearance is not an authorization to deviate from any rule, regulation, or minimum altitude nor to conduct unsafe operations of an aircraft.Clearances are issued based on a prediction of known traffic and known physical airport conditions.An ATC clearance is an authorization for an aircraft to proceed under specified conditions within controlled airspace.Chart Supplement as well as several online sources such as Clearance delivery frequencies can be found in the U.S.Clearance delivery has no control function and is used solely as the name implies, for the delivery of clearances.Where clearance delivery is not a dedicated frequency, ground control absorbs this function.Clearance delivery is established at busy airports to facilitate the delivery of flight instructions without congesting the ground frequency. This may be referred to as resistance training. Examples: walking, jogging, dancing, bicycling, basketball, soccer, swimming These are activities that are intense enough and performed long enough to maintain or improve one’s heart and lung fitness. But it is important to remember that some exercise is better than none, and that most everyone can participate in some form of exercise safely.Īerobic/Cardiovascular physical activity. Performing different types of exercises can expand the range of benefits even further. Types of ExerciseĪll types of exercises offer health benefits. However, busy lifestyles and an environment that encourages being sedentary for many hours of the day (driving door-to-door, sitting at an office desk, relaxing for the evening in front of a television) have led to exercise ranking low as a priority for many people. Research strongly supports its benefits across a range of physical and mental health conditions for people of all ages. Despite its various connotations, the underlying essence of ‘low-key’ in any situation boils down to simplicity, authenticity, limitation, and categorization, whether explicitly or implicitly conveyed.Although many people view exercise as a way to lose weight, it plays a key role in the wellbeing of the body beyond weight loss. ‘Low-key’ is a versatile term that carries multiple meanings in today’s colloquial context. If referring to a secret or someone secretive, use low-key.Įxamples: “She’s always low-key”, “Better keep it low-key”, “I’m okay with the low-key lifestyle, but not with your family!”, or “Sorry, I’ve promised to keep it low-key.” Conclusion It means maintaining a low profile for various reasons, such as confidentiality, avoiding attention, or staying incognito.įor example, “Let’s keep things low-key until it’s official”, “To avoid getting caught, stay low-key and don’t show you’re drunk”, or “I prefer to be low-key about my achievements, not sure if it’s a good thing.” Maintaining confidentialityĪn alternative to secrecy is ‘low-key’, hinting at staying under the radar. We all know people who exaggerate things, both good and bad. SMH.” Guarding against exaggerated enthusiasm. Mine’s the one that’s loud and obnoxious. For example, “I seriously admire people who are famous and rich but still live a low-key life” or “Oh, her family’s low-key, man. In slang, qualities are often positive and heart-warming. Use ‘low-key’ to describe something or someone who possesses these qualities. To express the essence of something or someoneĪ simple, humble, and down-to-earth persona embodies ‘low-key’ as a character sketch. I feel horrible’, or ‘He was irritated when you said that. For instance, ‘They were close to storming out of the meeting’, ‘It tasted good despite being stale. ‘Low-key’ casually measures something with minimal quantity, quality, or intensity. When providing an estimate or approximation However, it is informal slang and should not be used formally unless agreed upon. These use cases are relevant even in personal conversations. How to Use Low Key?Ĭonsidering there are multiple use-cases of “low-key” in the internet world that are merging into spoken communication, we’ll list all the popular use-cases and explore other possible applications of the slang online. Another parameter to consider when understanding and using low-key is the term’s placement. Every slang is contextual on social media, including low-key, which relies on its context to convey the correct meaning. The term has multiple meanings on social media, all equally relevant to the current online connotation of low-key. Besides meaning “keeping a low profile,” it also implies subtlety, a slight degree, a relaxed and carefree state, and being unnoticeable. Every slang word or acronym evolves in meaning, including low-key. This encourages free thinking and association of ideas, leading to creative solutions and innovative thinking. Users can jot down ideas as nodes and connect related ideas through branches. Idea Mapping: Mind mapping software is an effective tool for brainstorming and idea generation.The hierarchical structure of mind maps helps in understanding the project's timeline and critical milestones. Users can create a mind map to outline the project scope, identify deliverables, assign responsibilities, and establish dependencies. Project Planning: Mind mapping software is valuable for project planning as it allows users to break down complex projects into manageable tasks and subtasks.The visual nature of mind maps helps users see the bigger picture while also focusing on specific details. Users can create to-do lists, set priorities, and track progress by adding tasks and subtasks to their mind maps. Productivity: Mind mapping software helps improve productivity by providing a structured and visual way to organize ideas, tasks, and information.Here's how it can be beneficial in each of these areas: Mind mapping software is widely used in various domains, including productivity, project planning, and idea mapping. The software allows for easy navigation and manipulation of the mind map, enabling users to expand or collapse branches, zoom in or out, and rearrange nodes as needed. Users can add text, images, icons, and other visual elements to enhance the representation of their ideas. Mind mapping software provides a user-friendly interface where users can create, edit, and rearrange nodes or elements representing ideas or concepts. Mind maps typically start with a central idea or topic, and then branch out into subtopics or related concepts. It is based on the concept of mind maps, which are graphical representations of concepts or ideas linked together by branches. Mind mapping software is a tool that allows users to visually organize their thoughts, ideas, and information in a hierarchical and interconnected manner. |
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